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Identify very high-risk patients with
ASCVD to determine their recommended LDL-C level

More than 90% of patients who've had a myocardial infarction or stroke are at very high risk1

Reviewing the history of major CV events and presence of high-risk conditions determines if your patients with ASCVD are at very high risk.2

The 2018 AHA/ACC/Multi-society guideline definition of patients with ASCVD at very high risk2

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MULTIPLE MAJOR EVENTS

Hypothetical male with multiple major events

TWo or More of these:

Recent ACS
(within 12 months)

Symptomatic PAD

Stroke

Myocardial infarction

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1 Major EVENT + multiple
HIGH-RISK CONDITIONS

Hypothetical Female with 1 major event + multiple high-risk conditions

One of these:

Recent ACS
(within 12 months)

Symptomatic PAD

Stroke

Myocardial infarction

And two or more of these:

Age 65+

History of CABG or PCI
(outside of the major ASCVD event)

CKD
(eGFR 15-59 mL/min/1.73 m2)

Diabetes

HeFH

Hypertension

History of CHF

Current smoker

Persistently elevated LDL-C (≥ 100 mg/dL)
despite maximally tolerated statin and ezetimibe

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Learn how often you should test your patients' LDL-C

ACS = acute coronary syndrome; ASCVD = atherosclerotic cardiovascular disease; CABG = coronary artery bypass graft; CHF = congestive heart failure; CKD = chronic kidney disease; eGFR = estimated glomerular filtration rate; HeFH = heterozygous familial hypercholesterolemia; PAD = peripheral artery disease; PCI = percutaneous coronary intervention.

  • References

    1. Muntner P, Orroth KK, Mues KE, et al. Evaluating a simple approach to identify adults meeting the 2018 AHA/ACC cholesterol guideline definition of very high risk for atherosclerotic cardiovascular disease. Cardiovasc Drugs Ther. 2022;36:475-481.
    2. Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCN A guideline on the management of blood cholesterol: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2019;73:3168-3209.